A REVIEW ON EFFECT OF PHOTOBIOMODULATION THERAPY ON OBESE MICE-HISTOLOGICAL CHANGES AND PROTEIN ANALYSIS

The effect of Photobiomodulation therapy on obesity is a growing area of interest, given its potential to influence cellular metabolism, inflammation, and tissue regeneration. This study aimed to evaluate the histological and protein-level changes induced by Photobiomodulation therapy in obese mice. Male or female mice were fed with high-fat diet to induce obesity and were subsequently treated with Photobiomodulation therapy at specific wavelengths, power densities, and dosages over a defined period. The results were analysed through histological examinations of adipose tissue, liver, and muscle, focusing on changes in fat deposition, inflammation, and fibrosis. Protein analysis, using techniques such as Western blot or ELISA, were conducted to measure biomarkers related to lipolysis, oxidative stress, and metabolic regulation and key inflammatory cytokines. Photobiomodulation therapy demonstrated significant effects on reducing fat deposition and optimizing tissue structure. Protein analysis revealed modulations in key markers of lipid metabolism and inflammation, suggesting that Photobiomodulation therapy effectively mitigates obesity-related metabolic dysfunction. These findings highlight the Photobiomodulation therapy as a promising, non-invasive intervention for addressing obesity-related tissue alterations and metabolic imbalance. Future studies should refine Photobiomodulation therapy parameters and explore the therapy’s long-term effects in preclinical and clinical models.